物料性质对中药实验室雾干燥机粘壁性的影响

物料性质对中药实验室雾干燥机粘壁性的影响

物料性质对中药实验室雾干燥机粘壁性的影响

中药提取物的性质与粘壁性的关系吸湿性 中药提取物的吸湿性是影响喷雾干燥的主要问题，中药浸膏粉吸湿后导致粉体粘性增强、分散性降低。因此，实验室雾干燥机在喷雾干燥过程中，粉体的吸湿性是造成粘壁现象或结成块状的主要原因。相对密度 提取液的相对密度对喷雾干燥的影响较为显著。提取液经浓缩后相对密度一般以控制在1．05～1．15为宜。但不同种类的中药提取液，其相对密度的适宜范围也不同。如冰黄五苓散提取液适宜的相对密度为1．18一1．22，实验室雾干燥机在进风温度、进风量不变的情况下，随着密度的增加，粘壁情况减轻，得粉率提高；但随着提取液密度的增加，导致药液流动性变差，易出现粘壁现象，并可引起喷头堵塞等问题。软化点 中药浸膏软化点低于进风温度是产生粘壁现象的主要原因。杜松等H o研究发现：中药浸膏实验室雾干燥机干燥过程存在一个“软化点”温度，超过这个温度，物料就容易塌陷粘壁。水提在喷雾干燥时粘壁情况不严重，而水提液经醇沉除杂后的药液及中药的高浓度乙醇提取液在喷雾干燥过程中易产生较为严重的粘壁现象，这是由于水提取液中含有淀粉等高玻璃化转变温度Tg物质，经醇沉后淀粉被除去，而高浓度乙醇提取液中淀粉含量极低，使得提取物的Tg低于喷雾干燥时的温度，则出现干燥物塌陷、变软，导致粘壁现象发生。李智等将甘草用不同质量分数(300，400，500，600，700 g／L)的乙醇溶液进行提取，然后将各提取液分别进行喷雾干燥，结果发现：使用600 g／L以上乙醇的提取物，在干燥时粘壁现象较为严重。另外，药液在喷雾干燥前须过筛，防止粗粒混入，阻塞喷嘴；过滤后的药液，最好在70一90℃保温，这样利于药液流动，能减少粘壁情况。辅料对防粘壁的作用 鉴于以上中药提取物本身的性质、特点及喷雾干燥时粘壁的情况，需要对中药提取物进行改性．常采用加入辅料的方法改变中药提取液的特性，以改善粘壁的情况。

英文版：

The effect of material properties on the adherence of the traditional Chinese medicine laboratory fog dryer

The relationship between the properties of the extract of Chinese medicine and the adherenceThe moisture absorption of the extract of the hygroscopic Chinese medicine is the main problem affecting the spray drying. The moisture absorption of the extract powder of traditional Chinese medicine leads to the enhancement of the viscosity of the powder and the decrease of the dispersibility. Therefore, in the process of spray drying, the moisture absorption of the powder is the main cause of the phenomenon of wall sticking or the formation of lump. The relative density of the relative density extract has a significant effect on the spray drying. The relative density of the extracted liquid after concentration is generally controlled from 1.05 to 1.15. But the suitable range of relative density of different kinds of traditional Chinese medicine extracts is different. Ice yellow Wuling powder extracting liquid suitable for relative density of 1.18 to 1.22, the inlet air temperature, air flow is constant, with the increase of density, reduce the wall sticking, powder rate to increase; but with the increasing density of liquid extract, lead to poor liquidity and prone to sticking to the wall, and can cause problems such as nozzle clogging.The softening point of the softening point of the Chinese medicine extract is lower than the air inlet temperature, which is the main cause of the wall sticking phenomenon. Du Song and other H o studies found that there is a "softening point" temperature in the drying process of the extract of Chinese medicine, which can easily collapse to the wall of the wall. The water in the spray drying when sticking to the wall, the case is not serious, and the water extract by ethanol precipitation of high concentration of ethanol in liquid impurities and traditional Chinese medicine extraction is a serious phenomenon of sticking to the wall is easy to produce in the spray drying process of liquid, which is due to the water extraction of starch containing high glass transition temperature Tg material liquid. After the starch was removed by ethanol precipitation, and high concentration of ethanol extraction liquid starch content is very low, the extract of Tg is lower than the temperature of spray drying, there is dry collapse, soft, lead to the occurrence of the phenomenon of adhering wall. Li Zhi and other licorice extracts were extracted with different mass fraction (300400500600700 g / L) of ethanol solution. Then the extracts were spray dried separately. It was found that the extract with 600 g / L ethanol was more serious when drying. In addition, the liquid should be sifted before spray drying to prevent coarse particles from mixing and obstruct the nozzle. After filtration, the best solution should be kept at 70 to 90 degrees, so that it can help the liquid flow and reduce the sticky wall.The effect of excipients on the anti sticking wall is due to the nature and characteristics of the above extracts and the situation of sticky wall when spray drying. It is necessary to modify the extract of traditional Chinese medicine. The method of adding excipients is often used to change the characteristics of the extract of traditional Chinese medicine, so as to improve the condition of sticky wall.